the human mitochondrial genome

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The Human Mitochondrial Genome
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Publisher : Academic Press
Release Date :
ISBN 10 : 0128226420
Pages : 596 pages
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The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

The Human Mitochondrial Genome

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore,

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The Human Mitochondrial Genome

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore,

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High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics  Function  and Signals of Selection in Cancer

Known as the energy powerhouses of the cell, mitochondria carry their own genomes, and encode for key cellular respiration proteins. Carrying multiple copies per cell, a given mitochondrial DNA (mtDNA) variant can be present at varying proportions, termed heteroplasmy. MtDNA is acquired exclusively through maternal inheritance and becomes stochastically replicated

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Human Mitochondrial DNA and the Evolution of Homo sapiens

Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA,

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The Evolution of Human Mitochondrial DNA

Download or read online The Evolution of Human Mitochondrial DNA written by Rebecca Louise Cann, published by Unknown which was released on 1982. Get The Evolution of Human Mitochondrial DNA Books now! Available in PDF, ePub and Kindle.

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Mitochondrial DNA

The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us.

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Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer

Download or read online Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer written by Mansoureh Akouchekian, published by Cuvillier Verlag which was released on 2008. Get Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer Books now! Available in PDF, ePub and Kindle.

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Normal and Disease related Sequence Variants of the Human Mitochondrial Genome

Download or read online Normal and Disease related Sequence Variants of the Human Mitochondrial Genome written by Patcharee Lertrit, published by Unknown which was released on 1992. Get Normal and Disease related Sequence Variants of the Human Mitochondrial Genome Books now! Available in PDF, ePub and Kindle.

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The Role of MGME1 in Maintenance of the Human Mitochondrial Genome

Download or read online The Role of MGME1 in Maintenance of the Human Mitochondrial Genome written by Thomas Joseph James Nicholls, published by Unknown which was released on 2014. Get The Role of MGME1 in Maintenance of the Human Mitochondrial Genome Books now! Available in PDF, ePub and Kindle.

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Mitochondrial Gene Expression

This volume details the most recent advancements in the field of mitochondrial gene expression. Chapters guide readers through methods and protocols on mtDNA replication, transcription, and translation to membrane insertion of the mtDNA-encoded protein products. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to

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Regulation of Human Mitochondrial Gene Expression

Human mitochondrial DNA is a distinct, compact genetic system that encodes proteins crucial for energy metabolism in the cell. Due to its reduced size and relatively simple organisation, all the regulatory factors directing the expression of the mitochondrial genome are encoded by nuclear DNA. It is evident that mitochondrial gene

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Human Mitochondrial DNA Evolution in Papua New Guinea

Download or read online Human Mitochondrial DNA Evolution in Papua New Guinea written by Mark Allen Stoneking, published by Unknown which was released on 1988. Get Human Mitochondrial DNA Evolution in Papua New Guinea Books now! Available in PDF, ePub and Kindle.

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MITOMAP

MITOMAP uses the mtDNA sequence as the unifying element for bringing together information on mitochondrial genome structure and function, pathogenic mutations, and their clinical characteristics, population associated variation, and gene-gene interactions.

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Detection of Sequence Variation in the HVII Region of the Human Mitochondrial Genome in 689 Individuals Using Immobilized Sequence Specific Oligonucleotide Probes

We have developed a rapid, immobilized probe-based assay for the detection of sequence variation in the hyper-variable segment II (HVII) of the mitochondrial DNA (mtDNA) control region. Using a panel of 17 sequence-specific oligonucleotide (SSO) probes immobilized on nylon membrane strips, we typed 689 individuals from four population groups. The genetic diversity

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Seven Daughters Of Eve

Describes how a scientist linked the DNA found in a five-thousand-year-old man to modern-day relatives and explains how all modern individuals can trace their genetic makeup back to prehistoric times to seven primeval women.

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