signal transduction in physiology pathophysiology and drug discovery

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Biased Signaling in Physiology  Pharmacology and Therapeutics
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Publisher : Elsevier
Release Date :
ISBN 10 : 0124115071
Pages : 316 pages
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Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Biased Signaling in Physiology  Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors

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Biomedical Index to PHS supported Research  pt  A  Subject access A H

Download or read online Biomedical Index to PHS supported Research pt A Subject access A H written by Anonim, published by Unknown which was released on 1993. Get Biomedical Index to PHS supported Research pt A Subject access A H Books now! Available in PDF, ePub and Kindle.

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NIH Almanac

Download or read online NIH Almanac written by National Institutes of Health (U.S.). Division of Public Information, published by Unknown which was released on 1992. Get NIH Almanac Books now! Available in PDF, ePub and Kindle.

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Regulation of Signal Transduction in Human Cell Research

This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources

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Physiological Research

Download or read online Physiological Research written by Anonim, published by Unknown which was released on 2005. Get Physiological Research Books now! Available in PDF, ePub and Kindle.

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Signal Transduction

Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that

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The Journal of NIH Research

Download or read online The Journal of NIH Research written by Anonim, published by Unknown which was released on 1995. Get The Journal of NIH Research Books now! Available in PDF, ePub and Kindle.

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Signal Transduction  Pathways  Mechanisms and Diseases

Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

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New Scientist

Download or read online New Scientist written by Anonim, published by Unknown which was released on 2006. Get New Scientist Books now! Available in PDF, ePub and Kindle.

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Physiology and Pathophysiology of the Heart

The third edition includes 14 new chapters covering topics that were not covered in the second edition. These include two new chapters on the molecular structure of ion channels and several new chapters on the ionic channels of myocardial cells, vascular smooth muscle cells, and endothelial cells. New chapters are also

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Cancer Research

Download or read online Cancer Research written by Anonim, published by Unknown which was released on 2001. Get Cancer Research Books now! Available in PDF, ePub and Kindle.

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Hormonal Signaling in Biology and Medicine

Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug

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European Research Centres  A N

Download or read online European Research Centres A N written by Anonim, published by Stockton Press which was released on 1994-11. Get European Research Centres A N Books now! Available in PDF, ePub and Kindle.

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Directory of American Research and Technology

Identifies non-government facilities active in commercial research, including development of products and processes. Arrangement is alphabetic, geographic, and by concept classification.

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Nature

Download or read online Nature written by Sir Norman Lockyer, published by Unknown which was released on 1869. Get Nature Books now! Available in PDF, ePub and Kindle.

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