protein homeostasis diseases

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Protein Homeostasis Diseases
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Publisher : Academic Press
Release Date :
ISBN 10 : 9780128191323
Pages : 450 pages
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Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Protein Homeostasis Diseases

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components

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Chaperones  Protein Homeostasis and Protein Aggregation Diseases

Download or read online Chaperones Protein Homeostasis and Protein Aggregation Diseases written by Harm Harmannus Kampinga,Rijksuniversiteit Groningen, published by Unknown which was released on 2014. Get Chaperones Protein Homeostasis and Protein Aggregation Diseases Books now! Available in PDF, ePub and Kindle.

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Protein Homeostasis

Proper expression, folding, transport, and clearance of proteins is critical for cell function. Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded. Translocation machineries, proteasomes, and autophagic activities help to localize and degrade proteins as necessary. Stress and aging can cause

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Impairment of Protein Homeostasis in Parkinson s Disease

Download or read online Impairment of Protein Homeostasis in Parkinson s Disease written by Maike Lichtenberg, published by Unknown which was released on 2011. Get Impairment of Protein Homeostasis in Parkinson s Disease Books now! Available in PDF, ePub and Kindle.

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Finding Balance in Huntington s Disease

The disruption of protein quality control networks that ensure proper folding and degradation of cellular proteins is likely central to pathology in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and other "protein misfolding" diseases (La Spada and Taylor, 2010; Wilkinson et al., 2010). A detailed understanding of the proteostasis network

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Proteostasis and Disease

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and

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Proteostasis and Chaperone Surveillance

Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis,

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Protein Homeostasis

The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting

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Protein Homeostasis Diseases

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components

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Protein Metabolism and Homeostasis in Aging

Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging

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Proteostasis and Disease

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and

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Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health   Disease

Download or read online Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health Disease written by Anonim, published by Unknown which was released on 2016. Get Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health Disease Books now! Available in PDF, ePub and Kindle.

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Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

Download or read online Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases written by Diana Fernandes Lázaro,Tiago F. Outeiro,Arianna Bellucci,Patrik Brundin, published by Frontiers Media SA which was released on 2020-02-20. Get Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases Books now! Available in PDF,

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Calcium Binding Proteins in Health and Disease

Calcium-Binding Proteins in Health and Disease includes the papers prepared by the invited speakers as well as many of the free communications. The contributions are grouped according to their general subject matter, based on the classification made by the authors, e.g., Extracellular Metabolism: Calcium Homeostasis; Low-Affinity Calcium-Binding Proteins. There

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Immunity  Tumors and Aging  The Role of HSP70

The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of

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