protein folding in silico

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Protein Folding in Silico
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Publisher : Elsevier
Release Date :
ISBN 10 : 1908818255
Pages : 240 pages
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Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The opening chapters discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half of the book covers a variety of topics including ligand binding site recognition, the "fuzzy oil drop" model and its use in simulation of the polypeptide chain, and misfolded proteins. The book ends with an overview of a number of other ab initio methods for protein structure predictions and some concluding remarks. Discusses a range of ab initio models for protein structure prediction Introduces a unique model based on experimental observations Describes various methods for the quantitative assessment of the presented models from the viewpoint of information theory

Protein Folding in Silico

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts

GET BOOK!
Protein Folding in Silico

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts

GET BOOK!
Protein Folding in Silico

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts

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In Silico Study of Amyloid  beta  protein Folding Relevant to Alzheimer s Disease

Download or read online In Silico Study of Amyloid beta protein Folding Relevant to Alzheimer s Disease written by Alfonso Ramon Lam Ng, published by Unknown which was released on 2008. Get In Silico Study of Amyloid beta protein Folding Relevant to Alzheimer s Disease Books now! Available in PDF, ePub

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Multiscale Approaches to Protein Modeling

The book gives a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. It approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems.

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Computational Protein Design

The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the

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Protein Folding in the Cell

This volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new--10 years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics

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Structure Function Relation In Proteins

The protein structure seems to be the materialization of the secret of Nature. The structures of proteins seem to be at the first glance the completely random arrangements of the ribbon-like polypeptide chain. The short visual analysis reveals the existence of some ordered fragments called helices or beta-forms. The order

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The objective of this book is to present the strategies employed by living organisms on a molecular level and to help understand the basics of Systems Biology. Its content is organized in a way to meet the exponential growth in the volume of biological knowledge, and the need for a

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Protein Misfolding Diseases

This detailed book gathers a broad collection of experimental approaches to assist researchers in setting up different methods to investigate protein conformational disorders. Beginning with a section on assays focusing on biophysical approaches to study protein (mis)folding, the volume continues with sections on cellular and proteostasis assays as well

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Multiscale Approaches to Protein Modeling

The book gives a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. It approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems.

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Abridged Thermodynamic and Thermochemical Tables

The phenomenon of amyloidosis has attracted the attention of numerous researchers for two main reasons: (1) it involves unexpected changes in protein conformation (without chemical intervention) and (2) has practical implications, such as elucidating the mechanisms which drive neurodegenerative diseases carries. In particular, understanding the process of amyloidosis is a fundamental prerequisite

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Combining in Vivo and in Silico Screening for Protein Stability

In any protein design endeavor, thermal stability is an important issue. Increasing protein stability is currently one of the main goals of the field of protein design as well as the biomedical industry. It is important for developing stable protein-based therapeutics and ultimately enhances our understanding of the principles of

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Combining in Vivo and in Silico Screening for Protein Stability

In the in vivo 'chimeric' screen a target protein is expressed as a fusion protein with a DNA binding domain fused at the N-terminus and a transactivation domain at the C-terminus. This three-component fusion protein acts as a functional transcription factor for a reporter gene. If the central target protein

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Molecular Biology of the Cell

Download or read online Molecular Biology of the Cell written by Bruce Alberts, published by Unknown which was released on 2004. Get Molecular Biology of the Cell Books now! Available in PDF, ePub and Kindle.

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