prodrug design

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Prodrug Design
Author :
Publisher : Academic Press
Release Date :
ISBN 10 : 0128035579
Pages : 84 pages
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Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference. Offers unique, detailed overview of Prodrug research and literature Provides detailed chemical structures Includes Prodrug listing by therapeutic area

Prodrug Design

Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its

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Prodrugs and Targeted Delivery

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing

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Prodrugs Design

The prodrug approach is a promising and well established strategy for the development of new entities that possess superior efficacy, selectivity and reduced toxicity. Hence an optimized therapeutic outcome can be accomplished using this approach. Prodrug design is becoming more elaborate in the development of efficient and selective drug delivery

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Prodrug Designing of Nsaids

Separation of therapeutic effects from toxicity is a valuable goal in the drug development process. Prodrug design is a part of the general drug discovery process, in which a unique combination of therapeutically active substances is observed to have desirable pharmacological effects. In human therapy prodrug designing has given successful

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Design of Prodrugs

Download or read online Design of Prodrugs written by Hans Bundgaard, published by Elsevier Publishing Company which was released on 1985. Get Design of Prodrugs Books now! Available in PDF, ePub and Kindle.

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Prodrugs

These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic

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Prodrug Design  Perspectives  Approaches and Applications in Medicinal Chemistry

Download or read online Prodrug Design Perspectives Approaches and Applications in Medicinal Chemistry written by Anonim, published by Unknown which was released on 2022-01-22. Get Prodrug Design Perspectives Approaches and Applications in Medicinal Chemistry Books now! Available in PDF, ePub and Kindle.

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Recent Advancement in Prodrugs

Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome

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Drug Absorption Evaluation  Prodrug Design and Intestinal Transporter Expression by Genechip Analysis

Download or read online Drug Absorption Evaluation Prodrug Design and Intestinal Transporter Expression by Genechip Analysis written by Duxin Sun, published by Unknown which was released on 2002. Get Drug Absorption Evaluation Prodrug Design and Intestinal Transporter Expression by Genechip Analysis Books now! Available in PDF, ePub and Kindle.

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Hydrolysis in Drug and Prodrug Metabolism

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to

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Development of Macromolecular Prodrug Conjugates for the Diagnosis and Treatment of Musculoskeletal Diseases

Macromolecular prodrug conjugate is a promising strategy for better diagnosis and treatment of musculoskeletal diseases. Our lab has pioneered this effort and has successfully developed multiple prodrug formulations. The general approach we have taken is to incorporate active ingredient (AI, including imaging probe or therapeutic agents) containing monomers into water-soluble

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Recent Advancement in Prodrugs

Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome

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Use of the Combination of Prodrug Design and Salt Optimization

Download or read online Use of the Combination of Prodrug Design and Salt Optimization written by Anders Bach Nielsen, published by Unknown which was released on 2004. Get Use of the Combination of Prodrug Design and Salt Optimization Books now! Available in PDF, ePub and Kindle.

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The Organic Chemistry of Drug Design and Drug Action

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug

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Textbook of Drug Design and Discovery  Third Edition

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from

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