perinatal and developmental epigenetics

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Perinatal and Developmental Epigenetics
Author :
Publisher : Academic Press
Release Date :
ISBN 10 : 9780128217856
Pages : 432 pages
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Increasing evidence shows the perinatal periods see intense epigenetic activity, enabling the fine-tuning of developmental processes in response to changing environment conditions. Perinatal and Developmental Epigenetics, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development, opening with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility, while concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood. Examines disease onset stemming from epigenetic changes during the perinatal periods Features contributions from international experts in the field, across basic biology, disease research, and drug discovery Offers intervention strategies to mitigate adverse developmental programming to improve health outcomes

Perinatal and Developmental Epigenetics

Increasing evidence shows the perinatal periods see intense epigenetic activity, enabling the fine-tuning of developmental processes in response to changing environment conditions. Perinatal and Developmental Epigenetics, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for

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Epigenetics  the Environment  and Children   s Health Across Lifespans

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the

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Prenatal Stress and Child Development

This book examines the complex impact of prenatal stress and the mechanism of its transmission on children's development and well-being, including prenatal programming, epigenetics, inflammatory processes and the brain-gut microbiome. It analyzes current findings on prenatal stressors affecting pregnancy, including preconception stress, prenatal maternal depression, anxiety and pregnancy specific anxieties.

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The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety

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Perinatal Programming

Perinatal Programming addresses the environment-dependent setting of fundamental life functions and dispositions for diseases in developmental periods during pregnancy and in early infancy. It provides a new view of the origins of health and diseases. To realize these associations may enable us to prevent diseases for the long term. This

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Developmental Origins of Health and Disease

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the

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Environmental Epigenetics

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks

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Epigenetics of the Immune System

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition,

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Handbook of Prenatal and Perinatal Psychology

The handbook synthesizes the comprehensive interdisciplinary research on the psychological and behavioral dimensions of life before, during, and immediately after birth. It examines how experiences during the prenatal period are associated with basic physiological and psychological imprints that last a lifetime and explores the ways in which brain networks reflect

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Hypoxia and Human Diseases

This book contains a total of 21 chapters, each of which was written by experts in the corresponding field. The objective of this book is to provide a comprehensive and updated overview of cellular and molecular mechanisms underlying hypoxia's impacts on human health, as well as current advances and future directions

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Nutrition and Epigenetics

Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary

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Epigenetic Clocks

"Maternal prenatal anxiety and depression are associated with adverse developmental outcomes that vary markedly at the level of the individual child. Epigenetic clocks, a tool used to calculate biological age estimates on the basis of DNA methylation information, have emerged as clinically relevant biomarkers for adverse health outcomes in adults.

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Epigenetics and Neuroendocrinology

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system (CNS) and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized

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Epigenetics in Psychiatry

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances

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Perinatal Programming of Neurodevelopment

The development of the brain and nervous system is shaped not just by a genetic program, but also by the effects of multiple environmental stimuli. There are currently no book-length treatments of perinatal neurodevelopment. The proposed book seeks to fill this gap by presenting a collection of chapters from leading

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