palladium catalyzed modification of nucleosides nucleotides and oligonucleotides

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Palladium Catalyzed Modification of Nucleosides  Nucleotides and Oligonucleotides
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Publisher : Unknown
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ISBN 10 : 9780128112922
Pages : 325 pages
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Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. This valuable work provides some of the key synthetic protocols for these reactions and is the latest volume in the Latest Trends in Palladium Chemistry series, edited by Professor Anant Kapdi and Professor Debabrata Maiti. Most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity. It has therefore become a necessity to have a comprehensive database of the catalytic reactions that could provide direct access to such synthetically and commercially viable molecules. Additionally, applications of chemically modified nucleotides as lab reagents and utility of synthetic oligonucleotides as therapeutics have further enhanced the need for a comprehensive overview of the field. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist

Palladium Catalyzed Modification of Nucleosides  Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. This valuable work provides some of the

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Palladium Catalyzed Modification of Nucleosides  Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols

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Chemistry of Nucleic Acids

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic

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Nucleic Acids Chemistry

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as

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Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field

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Strategies for Palladium Catalyzed Non directed and Directed C H Bond Functionalization

Strategies for Palladium-Catalyzed Non-directed and Directed C-H Bond Functionalization portrays the complete scope of these two aspects of C-H bond functionalization in a single volume for the first time. Featured topics include the influence of palladacyclic systems in C-H bond functionalization (need for newer catalytic systems for better efficiency), mechanistic

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New Trends in Cross Coupling

Palladium-catalysed cross-coupling reactions constitute a powerful class of chemical methods for the creation of carbon-carbon and carbon-heteroatom bonds used in organic synthesis, famously recognized by the 2010 Nobel Prize awarded to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki ‘for palladium-catalysed cross-couplings in organic synthesis.’ These methods have become ubiquitous in

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C H and C X Bond Functionalization

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book,

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Synthesis of Therapeutic Oligonucleotides

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in

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Advances in Heterocyclic Chemistry

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry

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Modified Nucleic Acids

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic

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Palladacycles

Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a

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Graphene Based Electrochemical Sensors for Biomolecules

Graphene-Based Electrochemical Sensors for Biomolecules presents the latest on these nanomaterials that have gained a lot of attention based on their unique properties of high mechanical flexibility, large surface area, chemical stability, superior electric and thermal conductivities that render them great choices as alternative electrode materials for electrochemical energy storage

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Chemical Synthesis of Nucleoside Analogues

Compiles current tested and proven approaches tosynthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists fromaround the world, this book brings together and describes testedand proven approaches for the chemical synthesis of common familiesof nucleoside analogues. Readers will learn to create newnucleoside analogues with desired therapeutic properties by using

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Nucleic Acids in Chemistry and Biology

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into

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