novel sensitizing agents for therapeutic anti egfr antibodies

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Novel Sensitizing Agents for Therapeutic Anti EGFR Antibodies
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Publisher : Academic Press
Release Date :
ISBN 10 : 9780128215845
Pages : 300 pages
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Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies presents an in-depth description of sensitizers to overcome resistance to anti-EGFR targeted antibody therapies in cancer, including novel engineered antibody drugs or other sensitizers. It gives an insight into the landscape of anti-EGFR based cancer treatment, the challenges of targeted therapy, and a glimpse into the future of antibody therapy. The book offers pertinent basic science information on strategies used for the rational design and discovery of novel sensitizing agents, and, in addition, translational studies involving pre-clinical and clinical design and execution with these novel agents. It covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on EGFR blockage resistance, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new anticancer sensitizers for anti-EGFR drug resistance. This book is an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new therapeutic agents to overcome resistance to anti-EGFR treatments. Presents detailed description of history, chemistry, mechanism of action, structure-function relationships, pharmacology, side effects, dosing, and formulation of new sensitizers to anti-EGFR antibodies Provides molecular structures for all novel anticancer drugs and strategies to overcome resistance of anti-EGFR antibodies Encompasses up-to-date information on the cancer drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in the emerging areas of precision medicine

Novel Sensitizing Agents for Therapeutic Anti EGFR Antibodies

Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies presents an in-depth description of sensitizers to overcome resistance to anti-EGFR targeted antibody therapies in cancer, including novel engineered antibody drugs or other sensitizers. It gives an insight into the landscape of anti-EGFR based cancer treatment, the challenges of targeted therapy, and a

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Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have

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Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, Volume Four in the Cancer Sensitizing Agents for Chemotherapy Series focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been

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Sensitization of Cancer Cells for Chemo Immuno Radio therapy

This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile

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Resistance to Immunotherapeutic Antibodies in Cancer

​​​​The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective,

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Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical

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Novel Therapies in Head and Neck Cancer  Beyond the Horizon

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers

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Therapeutic Strategies to Overcome ALK Resistance in Cancer

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK,

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The Molecular Basis of Cancer E Book

Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer;

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Abeloff s Clinical Oncology E Book

Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it

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Molecular Pathomechanisms and New Trends in Drug Research

Knowledge of the basic mechanisms of human disease is essential for any student or professional engaged in drug research and development. Functional gene analysis (genomics), protein analysis (proteomics), and other molecular biological techniques have made it possible to understand these cellular processes, opening up exciting opportunities for no

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Ovarian Cancer

Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic,

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Clinical Radiation Oncology E Book

Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and

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