monoclonal antibodies

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Monoclonal Antibodies
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Publisher : Woodhead Publishing
Release Date :
ISBN 10 : 0081002971
Pages : 224 pages
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Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies. Discusses the challenges to develop MAbs for intravenous (IV) and subcutaneous delivery (SC) Presents strategies to meet the challenges in development of MAbs for SC and IV administration Discusses the use of biophysical analytical tools coupled with MAb engineering to understand what governs MAb properties at high concentration

Monoclonal Antibodies

Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design

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Monoclonal Antibodies

This book represents the distillation and critical evaluation of many hundreds of publications relating to the production and use of antibodies. Therefore it is restricted to the "core" techniques of production and handling of antibodies, and their use in studies of antigen analysis, purification and localization.

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Monoclonal Antibodies

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments

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Drug Induced Liver Injury

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver

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Monoclonal Antibody Production

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for

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Therapeutic Monoclonal Antibodies

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies

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Monoclonal Antibodies

This book is a printed edition of the Special Issue "Monoclonal Antibodies" that was published in Antibodies

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Biosimilars of Monoclonal Antibodies

Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts,

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Monoclonal Antibodies

This book describes, in detail, tested techniques for the produc-tion and use of monoclonal antibodies. It covers those aspects of interest to all scientists working with monoclonal antibodies and presents methods in a step-by-step format for easy refer-ence. The text serves as a laboratory manual; and discusses rationale behind each

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Monoclonal Antibodies in Cancer

Download or read online Monoclonal Antibodies in Cancer written by Jack A. Roth, published by Blackwell/Futura which was released on 1986. Get Monoclonal Antibodies in Cancer Books now! Available in PDF, ePub and Kindle.

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Monoclonal Antibodies in Drug Development

Download or read online Monoclonal Antibodies in Drug Development written by J. Thomas August, published by Unknown which was released on 1982. Get Monoclonal Antibodies in Drug Development Books now! Available in PDF, ePub and Kindle.

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Monoclonal Antibodies

On August 7, 1975, Kohler and Milstein published in Nature (256:495) a report describing "Continuous cultures of fused cells secreting antibody of predefined specificity. " Their report has become a classic and has already had a profound effect on basic and applied research in biology and medicine. By the time the first Workshop on

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Monoclonal Antibodies in Endocrine Research

Download or read online Monoclonal Antibodies in Endocrine Research written by Robert E. Fellows,George S. Eisenbarth, published by Raven Press (ID) which was released on 1981. Get Monoclonal Antibodies in Endocrine Research Books now! Available in PDF, ePub and Kindle.

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Symposium on Monoclonal Antibodies for Therapy  Prevention  and in Vivo Diagnosis of Human Disease

Download or read online Symposium on Monoclonal Antibodies for Therapy Prevention and in Vivo Diagnosis of Human Disease written by H. Van de Donk, published by S Karger Ag which was released on 1990. Get Symposium on Monoclonal Antibodies for Therapy Prevention and in Vivo Diagnosis of Human Disease Books now!

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Production and Characterization of Monoclonal Antibodies Directed Against Cell Surface Antigens of Canine Keratinocytes and Induction of Antibody mediated Lesions in Stratified Squamous Epithelium Using Monoclonal Antibodies

Download or read online Production and Characterization of Monoclonal Antibodies Directed Against Cell Surface Antigens of Canine Keratinocytes and Induction of Antibody mediated Lesions in Stratified Squamous Epithelium Using Monoclonal Antibodies written by Maja M. Suter, published by Unknown which was released on 1988. Get Production and Characterization of Monoclonal Antibodies

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